Reversal, maintenance or progression: What happens to the liver after a virologic cure of hepatitis C?

摘要: A sustained virological response (SVR) from HCV (synonymous with cure) leads to decreased mortality, morbidity and improved quality of life, as well a reduced incidence liver disease progression, including failure, cirrhosis hepatocellular carcinoma. Large clinical trials comparing pre- post-treatment biopsies demonstrate improvements in inflammation fibrosis score following SVR. However, small subset patients display persistent hepatic and/or progress despite In addition conferring risk advanced pre-treatment is major factor for post-SVR this review, we discuss the mechanisms regression uncovered using experimental models highlight potential those few progression We also introduce current concepts fibrosis-dependent tumorigenesis disease. This article forms part symposium Antiviral Research on “Hepatitis C: next steps toward global eradication.”