Immunosuppressive effects of polyunsaturated fatty acids on antigen presentation by human leukocyte antigen class I molecules.

摘要: Dietary supplementation with polyunsaturated fatty acids (PUFAs) has immunosuppressive effects; however, the molecular targets of PUFAs and their mode action remain unclear. One possible target is antigen presentation to T cells through human leukocyte (HLA) class I pathway. Here we show that incorporation lowers cell susceptibility lysis by effector cells. Treatment B lymphoblast omega-6 PUFA arachidonic acid (AA) or omega-3 docosahexaenoic lowered alloreactive CD8+ approximately 20-25%. HLA surface levels rate endoplasmic reticulum (ER)-Golgi traffic were also reduced treatment. Calibration experiments showed 15% reduction in was not sufficient completely account for decreased lysis. However, significantly antigen-presenting cell-T conjugate formation, 30-40%. Taken together, our data first time an affect pathway lymphoblasts. Our findings suggest elimination self- pathogen-derived peptides effectors may be compromised dietary supplementation. In addition, PUFA-mediated changes ER-Golgi trafficking point a new area modulation immune responses.