Lactate dehydrogenases of Atlantic hagfish: physiological and evolutionary implications of a primitive heart isozyme
作者： B. Sidell , K. Beland
关键词:
摘要: Isozymes of lactate dehydrogenase from heart and muscle Atlantic hagfish show less functional divergence than those other fishes higher vertebrates. The enzyme (B4) displays a Michaelis constant for pyruvate lower substrate inhibition at moderate concentrations isozymes species. These properties support the hypothesis that ancestral vertebrate was (A4)-type also suggest role B4 in unusual physiology cardiac tissue which functions under sustained hypoxic conditions.
sciencemag.org
harvard.edu参考文章(15)
JH Wilkinson, WA Withycombe, Organ specificity and lactate-dehydrogenase activity. Some properties of human spermatozoal lactate dehydrogenase. Biochemical Journal. ,vol. 97, pp. 663- 668 ,(1965) , 10.1042/BJ0970663
S T Lim, R M Kay, G S Bailey, Lactate dehydrogenase isozymes of salmonid fish. Evidence for unique and rapid functional divergence of duplicated H-4 lactate dehydrogenases. Journal of Biological Chemistry. ,vol. 250, pp. 1790- 1800 ,(1975) , 10.1016/S0021-9258(19)41764-X
George F. Sensabaugh, Nathan O. Kaplan, A Lactate Dehydrogenase Specific to the Liver of Gadoid Fish Journal of Biological Chemistry. ,vol. 247, pp. 585- 593 ,(1972) , 10.1016/S0021-9258(19)45743-8
H.A. Dahl, H. Korneliussen, Lactate dehydrogenase isoenzymes in different types of muscle fibres in the Atlantic hagfish (Myxine glutinosa, L.) Comparative Biochemistry and Physiology Part B: Comparative Biochemistry. ,vol. 55, pp. 381- 385 ,(1976) , 10.1016/0305-0491(76)90308-4
D. M. Dawson, T. L. Goodfriend, N. O. Kaplan, N. O. Kaplan, Lactic Dehydrogenases: Functions of the Two Types Science. ,vol. 143, pp. 929- 933 ,(1964) , 10.1126/SCIENCE.143.3609.929
N. O. Kaplan, M. M. Ciotti, R. E. Bieber, M. Hamolsky, Molecular heterogeneity and evolution of enzymes. Science. ,vol. 131, pp. 392- 397 ,(1960) , 10.1126/SCIENCE.131.3398.392
Hans Gesser, Lars-Erik Sundell, Functional aspects of lactate dehydrogenase isoenzymes of atlantic salmon (Salmo salar L.) International Journal of Biochemistry. ,vol. 2, pp. 462- 472 ,(1971) , 10.1016/0020-711X(71)90084-X
A. R. Place, D. A. Powers, Genetic variation and relative catalytic efficiencies: lactate dehydrogenase B allozymes of Fundulus heteroclitus Proceedings of the National Academy of Sciences of the United States of America. ,vol. 76, pp. 2354- 2358 ,(1979) , 10.1073/PNAS.76.5.2354
R. D. Cahn, E. Zwilling, N. O. Kaplan, L. Levine, Nature and Development of Lactic Dehydrogenases: The two major types of this enzyme form molecular hybrids which change in makeup during development. Science. ,vol. 136, pp. 962- 969 ,(1962) , 10.1126/SCIENCE.136.3520.962
Clement L. Markert, Roger S. Holmes, Lactate dehydrogenase isozymes of the flatfish, Pleuronectiformes: Kinetic, molecular and immunochemical analysis Journal of Experimental Zoology. ,vol. 171, pp. 85- 103 ,(1969) , 10.1002/JEZ.1401710112