Mechanism of ROS scavenging and antioxidant signalling by redox metallic and fullerene nanomaterials: Potential implications in ROS associated degenerative disorders.

摘要: Abstract Background The balance between oxidation and anti-oxidation is believed to be critical in maintaining healthy biological systems. However, our endogenous antioxidant defense systems are incomplete without exogenous antioxidants and, therefore, there a continuous demand for prevent stress ageing associated disorders. Nanotechnology has yielded enormous variety of nanomaterials (NMs) which metallic carbonic (mainly fullerenes) NMs, with redox property, have been found strong scavengers ROS preclinical vitro vivo models. Scope review Redox activity metal based NMs membrane translocation time fullerene seem the major determinants scavenging potential exhibited by these NMs. A comprehensive knowledge about effects cellular signalling largely lacking. This compiles mechanisms as well aforementioned Major conclusions Direct interaction proteins does greatly affect corona/adsorption formation dynamics but such not provide explanation behind diverse outcomes induced Indirect interaction, however, that could occur via uptake dissolution, induction work central mode interaction. General significance usage would impact field nanomedicine. hold great promise future treatment related degenerative