Low serum testosterone levels in male psoriasis patients correlate with disease severity.

摘要: Psoriasis is a chronic inflammatory skin disease with genetic and autoimmune background. The involvement of sex hormones as trigger factor for psoriasis has been suspected. Recently, low serum testosterone associated diseases in males, the role unknown. To investigate levels male patients compared to control individuals regards severity psoriasis. A total 121 217 were enrolled. was documented using Area Severity Index (PASI). Serum testosterone, hormone binding globulin (SHBG), albumin analysed. Moreover, medication incidence metabolic syndrome recorded. In 52.1% patients, values detected. Compared cohort, (tT) free (fT) significantly lower. Despite psoriasis-specific medication, there significant inverse correlation between tT or fT PASI, irrespective age above below 40 years. Low also correlated prevalence syndrome. Nevertheless, without syndrome, higher PASI (≥10) lower values. addition, clinical symptoms deficiency. Severe testosterone. However, further studies are required whether this observation an epiphenomenon substitution might decrease