Molecular Imaging of Chemokine Receptor CXCR4 in Non-Small Cell Lung Cancer Using 68Ga-Pentixafor PET/CT: Comparison With 18F-FDG.
作者： Thorsten Derlin , Danny Jonigk , Johann Bauersachs , Frank M. Bengel
DOI: 10.1097/RLU.0000000000001092
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摘要: We report the case of a 62-year-old woman with history ST-elevation myocardial infarction who underwent 68Ga-Pentixafor PET/CT for characterization postinfarct inflammation. incidentally demonstrated marked CXCR4 expression in space-occupying lesion right upper lobe. Corresponding 18F-FDG showed increased metabolism, and subsequent biopsy revealed non-small cell lung cancer. Immunohistochemistry confirmed that was highly expressed on tumor cells. is novel CXCR4-targeted probe PET imaging CXCR4-positive tumors holds promise staging prognostic stratification. radionuclide therapy represents option metastasized diseases.
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