Phosphorylation of histone H3 Ser10 establishes a hierarchy for subsequent intramolecular modification events
作者： Stamatios Liokatis , Alexandra Stützer , Simon J Elsässer , Francois-Xavier Theillet , Rebecca Klingberg
DOI: 10.1038/NSMB.2310
关键词:
摘要: Phosphorylation of residues in the N-terminal tail histone H3 signals different biological outcomes. High-resolution NMR analyses now reveal a mechanistic hierarchy phosphorylation events, whereby Ser10 impedes Thr6 and Thr11 by PKC Chk1, respectively. Because both enzymes also target Ser10, this establishes an autoinhibitory feedback loop on tails.
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