Smart screening: approaches to efficient HTS.

摘要: Faced with the prospect of a rising number potential drug targets and given almost unlimited access to internal external chemistry resources, 'brute-force' approach high-throughput screening (HTS) is becoming increasingly unattractive. Pharmaceutical companies realize that they have both increase scope experiments improve on efficiency process per se. In acknowledging this development, hybrid strategies been suggested unite in silico vitro one integrated process. The partnering approaches believed exploit HTS much smarter more cost-efficient ways. This review will describe some recent applications new paradigm discuss impact integrating these novel discovery