Efficient Synthesis of 4‐ and 5‐Substituted 2‐Aminopyrimidines by Coupling of β‐Chlorovinyl Aldehydes and Guanidines
作者： Anna S. Komendantova , Alexander V. Komkov , Yulia A. Volkova , Igor V. Zavarzin
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摘要: … of β-chlorovinyl aldehydes with guanidine15 to circumvent these limitations (Scheme 1). Chlorovinyl aldehydes are readily available from enolizable ketones by the Vilsmeier–Haack …
sci-hub.se 参考文章(52)
Denis Kröger, Fabian Brockmeyer, Christoph Kahrs, A three-component reaction for rapid access to underexplored 1,3-thiazine-2-thiones. Organic and Biomolecular Chemistry. ,vol. 13, pp. 7223- 7229 ,(2015) , 10.1039/C5OB00377F
V. Král, Z. Arnold, Preparation, properties, and synthetic reactions of trimethylammoniodiformylmethylide Collection of Czechoslovak Chemical Communications. ,vol. 42, pp. 3455- 3463 ,(1977) , 10.1135/CCCC19773455
Natalia Andrushko, Vasyl Andrushko, Gerd König, Anke Spannenberg, Armin Börner, A New Approach to the Total Synthesis of Rosuvastatin European Journal of Organic Chemistry. ,vol. 2008, pp. 847- 853 ,(2008) , 10.1002/EJOC.200700813
Erin D. Anderson, Adam S. Duerfeldt, Kaicheng Zhu, Christopher M. Glinkerman, Dale L. Boger, Cycloadditions of Noncomplementary Substituted 1,2,3-Triazines Organic Letters. ,vol. 16, pp. 5084- 5087 ,(2014) , 10.1021/OL502436N
Natalija M. Krstić, Mira S. Bjelaković, Vladimir D. Pavlović, Koen Robeyns, Zorica D. Juranić, Ivana Matić, Irena Novaković, Dušan M. Sladić, New androst-4-en-17-spiro-1,3,2-oxathiaphospholanes. Synthesis, assignment of absolute configuration and in vitro cytotoxic and antimicrobial activities Steroids. ,vol. 77, pp. 558- 565 ,(2012) , 10.1016/J.STEROIDS.2012.01.021
Mohammad Movassaghi, Matthew D Hill, Synthesis of pyrimidines by direct condensation of amides and nitriles. Nature Protocols. ,vol. 2, pp. 2018- 2023 ,(2007) , 10.1038/NPROT.2007.280
Elena V Koroleva, K N Gusak, Zh V Ignatovich, Synthesis and applications of 2-aminopyrimidine derivatives as key intermediates in chemical synthesis of biomolecules Russian Chemical Reviews. ,vol. 79, pp. 655- 681 ,(2010) , 10.1070/RC2010V079N08ABEH004116
Masamichi Watanabe, Haruo Koike, Teruyuki Ishiba, Tetsuo Okada, Shujiro Seo, Kentaro Hirai, Synthesis and Biological Activity of Methanesulfonamide Pyrimidine- and N-Methanesulfonyl Pyrrole-Substituted 3,5-Dihydroxy-6-heptenoates, a Novel Series of HMG-CoA Reductase Inhibitors Bioorganic & Medicinal Chemistry. ,vol. 5, pp. 437- 444 ,(1997) , 10.1016/S0968-0896(96)00248-9
Atul Gupta, B. Sathish Kumar, Arvind S. Negi, Current status on development of steroids as anticancer agents The Journal of Steroid Biochemistry and Molecular Biology. ,vol. 137, pp. 242- 270 ,(2013) , 10.1016/J.JSBMB.2013.05.011
L. Rylski, F. Šorm, Z. Arnold, Darstellung von pyrimidinverbindungen aus β-dialdehydderivaten Collection of Czechoslovak Chemical Communications. ,vol. 24, pp. 1667- 1671 ,(1959) , 10.1135/CCCC19591667