Maternal diabetes and congenital anomalies in South Australia 1986-2000: a population-based cohort study.

摘要: BACKGROUND This study examined the risk of congenital anomalies in infants born South Australia to women with maternal diabetes a population-based cohort births over 15-year period, 1986–2000. Differences reporting, recording, and diagnosis preexisting mellitus, gestational impaired glucose tolerance make comparisons between studies difficult. In order compare published research, details research methods analytic approaches are required understand potential confounding, bias, effect modification that may occur. METHODS Data on from Australian Birth Defects Register were linked birth data Pregnancy Outcome Statistics Unit Department Health. This enabled information be pregnancy details, including status. RESULTS Between 1986 2000, prevalence mothers or was significantly higher than total population; relative = 2.01 (1.66–2.43) 1.19 (1.08–1.31), respectively. increased not modified by adjustments for age, ethnicity, other demographic factors, nor did rate change 15 years period. CONCLUSIONS The found diabetes. Larger needed determine which involved how their occurrence can reduced. Research (Part A), 2005. © 2005 Wiley-Liss, Inc.