E. coli K-12 recA::gfp microbial biosensor used for screening of anticancer and antidiabetic pharmacist residues
作者： Marzena Matejczyk , Włodzimierz Lewandowski , Stanisław Józef Rosochacki
DOI: 10.1080/19443994.2014.996013
关键词:
摘要: AbstractThe autofluorescent reporter of Escherichia coli K-12 recA::gfpmut2 strain containing a plasmid-borne transcriptional fusion between DNA-damage genotoxin-inducible recA promoter involved in the SOS regulon response and fast folding GFP (green fluorescent protein) variant gene-gfpmut2, have been used. GFP-based bacterial biosensors allowed for detection cytotoxic genotoxic anticancer drug—a cisplatin antidiabetic drug—metformin PBS buffer surface water. Experimental data indicated that genetic system was sensitive to applied drugs mixture drugs. RecA good bioindicator effect screening cisplatin, metformin, both Stronger reactivity water (0.001 mg/ml) metformin (0.3 mg/ml) treated samples prolonged incubation (up 24 h) obtained. The results showed E....
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