Hepatitis virus B and C infections are associated with an increased risk of non‐Hodgkin lymphoma: A nested case‐control study using a national sample cohort

摘要: BACKGROUND Hepatitis B virus (HBV) and hepatitis C (HCV) are suspected of being associated with non-Hodgkin lymphoma (NHL); however, persuasive data lacking. Hence, a nested large-population case-control study was performed to investigate such associations in Koreans. METHODS Data were collected from 929 patients NHL 3716 healthy subjects, who matched 1:4 for age, sex, income, region residence, the Korean Health Insurance Review Assessment Service-National Sample Cohort. The diagnoses HBV/HCV infection based on International Classification Diseases (version 10) codes. Conditional logistic regression models used assess odds ratios (ORs) respect HBV or HCV adjustment Charlson comorbidity index. RESULTS rates higher group (3.3% 1.3%, respectively) than control (0.9% 0.3%, respectively; P < .001 each). adjusted OR 3.25 (95% confidence interval [CI] = 1.99-5.31) 3.36 CI = 1.51-7.46) (P < .001 Subgroups categorized by age (<55 vs ≥55 years) sex showed significantly ORs NHL. Moreover, NHL ≥ 55 years those female HCV; <55 male also tended have HCV. CONCLUSION Infection either is