T lymphocyte T cell-B cell-activating molecule/CD40-L molecules induce normal B cells or chronic lymphocytic leukemia B cells to express CD80 (B7/BB-1) and enhance their costimulatory activity.

摘要: Activation-induced cell surface molecules are involved in mediating bidirectional T-B lymphocyte signaling that is important the induction of T or B effector functions. In this regard, T-BAM/CD40-L an activation-induced CD4+ molecule known to be inducing This report demonstrates on a Jurkat leukemia subclone (D1.1) nonlymphoid 293 kidney transfectants induce cells B-CLL express CD80 (B7/BB-1) manner specifically inhibited by anti-T-BAM/CD40-L mAb 5C8. Because molecules, such as CD80, deliver costimulatory signals augment proliferation, functional capacity T-BAM/CD40-L-primed and was studied. proliferative responses allogenic cells. Furthermore, priming Together, these studies demonstrate induces expression resting Moreover, enhances capacity. These suggest not only differentiative processes result Ab secretion, but also enable prime Ag-specific for subsequent clonal expansion.