Sex differences in naloxone- and Tyr-MIF-1-induced hypoalgesia.
作者： Martin Kavaliers , Duncan G.L. Innes
DOI: 10.1016/0196-9781(93)90077-T
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摘要: Reproductive adult male and female deer mice that received daily (7 days) injections of either the prototypic exogenous opiate antagonist, naloxone (1.0 mg/kg), or endogenous putative antiopioid tetrapeptide, Tyr-MIF-1 (Tyr-Pro-Leu-Gly amide; 1.0 10 followed by determinations thermal nociceptive sensitivity (hot-plate response) developed hypoalgesia. There were significant sex differences in this opioid blockade-induced associated analgesia, with displaying significantly greater hypoalgesia than females. Mice for 7 days without any accompanying (days 2-6 treatment) failed to show on day when they antagonist a measurement nociception. These results indicate there are both naloxone- Tyr-MIF-1-induced hypoalgesia, suggest pattern may be sexually dimorphic modulation aversive conditioning.
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