Deregulation of Scribble Promotes Mammary Tumorigenesis and Reveals a Role for Cell Polarity in Carcinoma

作者: Lixing Zhan , Avi Rosenberg , Kenneth C. Bergami , Min Yu , Zhenyu Xuan

DOI: 10.1016/J.CELL.2008.09.045

关键词:

摘要: Loss of cell polarity proteins such as Scribble induces neoplasia in Drosophila by promoting uncontrolled proliferation. In mammals, the role that polarity proteins play during …

参考文章(65)
Norman J. Kennedy, Roger J. Davis, Role of JNK in tumor development. Cell Cycle. ,vol. 2, pp. 199- 201 ,(2003)
D. Craig Allred, Syed K. Mohsin, Biological features of premalignant disease in the human breast. Journal of Mammary Gland Biology and Neoplasia. ,vol. 5, pp. 351- 364 ,(2000) , 10.1023/A:1009573710675
G Merlino, RB Dickson, GH Smith, LT Amundadottir, Johnson, Synergistic interaction of transforming growth factor alpha and c-myc in mouse mammary and salivary gland tumorigenesis. Cell Growth & Differentiation. ,vol. 6, pp. 737- 748 ,(1995)
Celina M. D'Cruz, Edward J. Gunther, Robert B. Boxer, Jennifer L. Hartman, Louis Sintasath, Susan E. Moody, James D. Cox, Seung I. Ha, George K. Belka, Alexander Golant, Robert D. Cardiff, Lewis A. Chodosh, c-MYC induces mammary tumorigenesis by means of a preferred pathway involving spontaneous Kras2 mutations Nature Medicine. ,vol. 7, pp. 235- 239 ,(2001) , 10.1038/84691
Guy Berchem, Robert R.B. Dickson, Michael D L Johnson, Laufey Thora Amundadottir, Sharyl S.J. Nass, Cooperation of TGF alpha and c-Myc in mouse mammary tumorigenesis: coordinated stimulation of growth and suppression of apoptosis. Oncogene. ,vol. 13, pp. 757- 765 ,(1996)
Bin Xiang, Senthil K Muthuswamy, None, Using three-dimensional acinar structures for molecular and cell biological assays. Methods in Enzymology. ,vol. 406, pp. 692- 701 ,(2006) , 10.1016/S0076-6879(06)06054-X
C. A. Schoenenberger, A. C. Andres, B. Groner, M. van der Valk, M. LeMeur, P. Gerlinger, Targeted c-myc gene expression in mammary glands of transgenic mice induces mammary tumours with constitutive milk protein gene transcription. The EMBO Journal. ,vol. 7, pp. 169- 175 ,(1988) , 10.1002/J.1460-2075.1988.TB02797.X
Cécilia De Lorenzo, Bernard M. Mechler, Peter J. Bryant, What is Drosophila telling us about cancer Cancer and Metastasis Reviews. ,vol. 18, pp. 295- 311 ,(1999) , 10.1023/A:1006381526008
K. G. Danielson, C. J. Oborn, E. M. Durban, J. S. Butel, D. Medina, Epithelial mouse mammary cell line exhibiting normal morphogenesis in vivo and functional differentiation in vitro Proceedings of the National Academy of Sciences of the United States of America. ,vol. 81, pp. 3756- 3760 ,(1984) , 10.1073/PNAS.81.12.3756