IDO expands human CD4+CD25high regulatory T cells by promoting maturation of LPS‐treated dendritic cells
作者： Marcelo Hill , Séverine Tanguy-Royer , Pierre Royer , Christine Chauveau , Kashif Asghar
关键词:
摘要: We have previously shown that human monocyte-derived dendritic cells (DC) express indoleamine 2,3-dioxygenase (IDO), as well several other enzymes of the kynurenine pathway at mRNA level upon maturation. The tolerogenic mechanisms this remain unclear. Here we show LPS-treated DC metabolize tryptophan far quinolinate. found IDO contributes to LPS and TNF-a + poly(I:C)induced maturation since inhibition using two different inhibitors impairs knock-down short-hairpin RNA also led diminished LPSinduced In line with these results, tryptophan-derived catabolites 3-hydroxyanthranilic acid 3-hydroxykynurenine increased LPStreated DC. Concerning molecular effect, acts an intermediate in LPS-induced production reactive oxygen species NF-jB activation, processes lead Finally, mature expand CD4 CD25 high regulatory T IDO-dependent manner. conclusion, constitutes leading expansion cells.
sci-hub.se 参考文章(44)
Clare Baecher-Allan, Julia A. Brown, Gordon J. Freeman, David A. Hafler, CD4+CD25+ regulatory cells from human peripheral blood express very high levels of CD25 ex vivo. Novartis Foundation symposium. ,vol. 252, pp. 67- 91 ,(2008) , 10.1002/0470871628.CH6
O Takikawa, T Kuroiwa, F Yamazaki, R Kido, Mechanism of interferon-gamma action. Characterization of indoleamine 2,3-dioxygenase in cultured human cells induced by interferon-gamma and evaluation of the enzyme-mediated tryptophan degradation in its anticellular activity. Journal of Biological Chemistry. ,vol. 263, pp. 2041- 2048 ,(1988) , 10.1016/S0021-9258(19)77982-4
Nathalie Vanderheyde, Valérie Verhasselt, Wim Vanden Berghe, Fabienne Willems, Guy Haegeman, Michel Goldman, N-Acetyl-l-Cysteine Inhibits Primary Human T Cell Responses at the Dendritic Cell Level: Association with NF-κB Inhibition Journal of Immunology. ,vol. 162, pp. 2569- 2574 ,(1999)
Clare Baecher-Allan, Julia A. Brown, Gordon J. Freeman, David A. Hafler, CD4+CD25high Regulatory Cells in Human Peripheral Blood Journal of Immunology. ,vol. 167, pp. 1245- 1253 ,(2001) , 10.4049/JIMMUNOL.167.3.1245
Ursula Grohmann, Roberta Bianchi, Maria L. Belladonna, Silvia Silla, Francesca Fallarino, Maria C. Fioretti, Paolo Puccetti, IFN-γ Inhibits Presentation of a Tumor/Self Peptide by CD8α−Dendritic Cells Via Potentiation of the CD8α+Subset The Journal of Immunology. ,vol. 165, pp. 1357- 1363 ,(2000) , 10.4049/JIMMUNOL.165.3.1357
M. Sono, T. Taniguchi, Y. Watanabe, O. Hayaishi, Indoleamine 2,3-dioxygenase. Equilibrium studies of the tryptophan binding to the ferric, ferrous, and CO-bound enzymes. Journal of Biological Chemistry. ,vol. 255, pp. 1339- 1345 ,(1980) , 10.1016/S0021-9258(19)86035-0
Lingqiao Zhu, Fang Ji, Yuan Wang, Yi Zhang, Qiang Liu, Jingwu Z. Zhang, Kouji Matsushima, Qi Cao, Yanyun Zhang, Synovial Autoreactive T Cells in Rheumatoid Arthritis Resist IDO-Mediated Inhibition Journal of Immunology. ,vol. 177, pp. 8226- 8233 ,(2006) , 10.4049/JIMMUNOL.177.11.8226
Zheng-Hong Qin, Yumei Wang, Masami Nakai, Thomas N. Chase, Nuclear Factor-κB Contributes to Excitotoxin-Induced Apoptosis in Rat Striatum Molecular Pharmacology. ,vol. 53, pp. 33- 42 ,(1998) , 10.1124/MOL.53.1.33
Hiroyuki Matsue, Dale Edelbaum, David Shalhevet, Norikatsu Mizumoto, Chendong Yang, Mark E. Mummert, Junichi Oeda, Hiroyuki Masayasu, Akira Takashima, Generation and function of reactive oxygen species in dendritic cells during antigen presentation. Journal of Immunology. ,vol. 171, pp. 3010- 3018 ,(2003) , 10.4049/JIMMUNOL.171.6.3010
Trevor W. Stone, L. Gail Darlington, Endogenous kynurenines as targets for drug discovery and development Nature Reviews Drug Discovery. ,vol. 1, pp. 609- 620 ,(2002) , 10.1038/NRD870