ClusPro in rounds 38 to 45 of CAPRI: Toward combining template-based methods with free docking.

摘要: Targets in the protein docking experiment CAPRI (Critical Assessment of Predicted Interactions) generally present new challenges and contribute to developments methodology. In rounds 38 45 CAPRI, most targets could be effectively predicted using template-based methods. However, server ClusPro required structures rather than sequences as input, hence we had generate dock homology models. The available templates also provided distance restraints that were directly used input server. We show here such an approach has some advantages. Free with reproduced interfaces suggested by weak or ambiguous while not reproducing others, resulting correct More recently developed fully automated TBM performs modeling thus can use component proteins input. performance server, freely for noncommercial at https://tbm.cluspro.org, is demonstrated predicting protein-protein CAPRI.