Cleavage of double-strand DNA by zinc complexes of dicationic 2,2'-dipyridyl derivatives.
作者： Yan An , Yan-Yong Lin , Hui Wang , Hong-Zhe Sun , Ming-Liang Tong
DOI: 10.1039/B616754C
关键词:
摘要: Two highly charged zinc complexes, [Zn(L1)3](ClO4)8·4H2O (1) and [Zn(L2)2Br](ClO4)5·H2O (2) (L1 = 5,5′-di(1-(triethylammonio)methyl)-2,2′-dipyridyl L2 5,5′-di(1-(tributylammonio)methyl)-2,2′-dipyridyl) were synthesized structurally characterized by crystallography. The atom in 1 shows a distorted octahedral sphere. Variable-pH NMR studies on demonstrated that the saturated six-coordinated [Zn(L1)3]8+ species can partially change into five-coordinated [Zn(L1)2(H2O)]6+ aqueous solution. 2 trigonal-bipyramidal average distance of coordinated Br to cationic N is ca 5.9 A, which comparable adjacent phosphodiesters DNA (ca. 6 A). Both complexes exhibited high nuclease activitiestowards cleavage supercoiled plasmid with activity being maximum under physiological pH. effective may be attributed strong electrostatic interaction metal moiety two positive pendants phosphodiester groups nucleic acid.
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Shin Aoki, Eiichi Kimura, Zinc−Nucleic Acid Interaction Chemical Reviews. ,vol. 104, pp. 769- 788 ,(2004) , 10.1021/CR020617U
Claudia Sissi, Paola Rossi, Fulvia Felluga, Fernando Formaggio, Manlio Palumbo, Paolo Tecilla, Claudio Toniolo, Paolo Scrimin, Dinuclear Zn(2+) complexes of synthetic heptapeptides as artificial nucleases. Journal of the American Chemical Society. ,vol. 123, pp. 3169- 3170 ,(2001) , 10.1021/JA005675G
Elisa Boseggia, Maddalena Gatos, Lorena Lucatello, Fabrizio Mancin, Stefano Moro, Manlio Palumbo, Claudia Sissi, Paolo Tecilla, Umberto Tonellato, Giuseppe Zagotto, Toward efficient Zn(II)-based artificial nucleases. Journal of the American Chemical Society. ,vol. 126, pp. 4543- 4549 ,(2004) , 10.1021/JA039465Q
X. M. Chen, R. Q. Wang, X. L. Yu, Tris(2,2'-bipyridine)zinc(II) Perchlorate Acta Crystallographica Section C-crystal Structure Communications. ,vol. 51, pp. 1545- 1547 ,(1995) , 10.1107/S0108270195000321
Marilena P. Fitzsimons, Jacqueline K. Barton, Design of a Synthetic Nuclease: DNA Hydrolysis by a Zinc-Binding Peptide Tethered to a Rhodium Intercalator Journal of the American Chemical Society. ,vol. 119, pp. 3379- 3380 ,(1997) , 10.1021/JA9633981
Akiko Nomura, Yukio Sugiura, Sequence-Selective and Hydrolytic Cleavage of DNA by Zinc Finger Mutants Journal of the American Chemical Society. ,vol. 126, pp. 15374- 15375 ,(2004) , 10.1021/JA045663L
Pin Yang, Weijuan Zheng, Zichun Hua, A simple copper(II)-L-histidine system for efficient hydrolytic cleavage of DNA. Inorganic Chemistry. ,vol. 39, pp. 5454- 5463 ,(2000) , 10.1021/IC0000146
Bernhard Bauer-Siebenlist, Franc Meyer, Etelka Farkas, Denis Vidovic, Jose Antonio Cuesta-Seijo, Regine Herbst-Irmer, Hans Pritzkow, Correlation of Structure and Function in Oligonuclear Zinc(II) Model Phosphatases Inorganic Chemistry. ,vol. 43, pp. 4189- 4202 ,(2004) , 10.1021/IC035491D
Kazuhiko Ichikawa, Máté Tarnai, Mohamed Khabir Uddin, Kou Nakata, Shiori Sato, Hydrolysis of natural and artificial phosphoesters using zinc model compound with a histidine-containing pseudopeptide. Journal of Inorganic Biochemistry. ,vol. 91, pp. 437- 450 ,(2002) , 10.1016/S0162-0134(02)00452-X
Kimberly D. Copeland, Marilena P. Fitzsimons, Robert P. Houser, Jacqueline K. Barton, DNA hydrolysis and oxidative cleavage by metal-binding peptides tethered to rhodium intercalators. Biochemistry. ,vol. 41, pp. 343- 356 ,(2002) , 10.1021/BI011793K