Blimp1: Driving Terminal Differentiation to a T
作者： Annie Xin , Stephen L. Nutt , Gabrielle T. Belz , Axel Kallies
DOI: 10.1007/978-1-4419-5632-3_8
关键词:
摘要: B lymphocyte maturation-induced protein-1 (Blimp1) is a transcrip-tional repressor expressed in diverse cell types. In the adaptive immune system, Blimp1 lymphocytes that have undergone effector differentiation. master regulator of plasma differentiation and plays important roles controlling T homeostasis can be induced by variety cytokines including IL-2, IL-4, IL-12, IL-21 addition to TCR co-stimulatory signals. Blimp1-deficient mice develop spontaneous inflammatory disease mediated infiltration activated cells into tissues. During responses required for as well short-lived CD8+ cytotoxic cells. Mounting evidence suggests common role terminal multiple subsets.
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