Transcriptomic analyses of RNA-binding proteins reveal eIF3c promotes cell proliferation in hepatocellular carcinoma.
作者： Tangjian Li , Shengli Li , Di Chen , Bing Chen , Tao Yu
DOI: 10.1111/CAS.13209
关键词:
摘要: RNA-binding proteins (RBPs) play fundamental roles in the RNA life cycle. The aberrant expression of RBPs is often observed human disease, including cancer. In this study, we screened for levels 1542 Cancer Genome Atlas liver hepatocellular carcinoma samples and found 92 consistently upregulated RBP genes HCC compared with normal samples. Additionally, undertook a Kaplan-Meier analysis that high 15 was associated poor prognosis patients HCC. Furthermore, eIF3c promotes cell proliferation vitro as well tumorigenicity vivo. Gene Set Enrichment Analysis showed positively KRAS, vascular endothelial growth factor, Hedgehog signaling pathways, all which are closely specific cancer-related gene sets. Our study provides basis further investigation molecular mechanism by development progression
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