House Dust Mite Allergy and Associated Allergen-Specific Immunotherapy in Allergic Asthma

摘要: Allergic asthma, an important subtype of asthma endotypes, is characterized by allergen-specific and Th2 cellmediated airway inflammation. Except for pharmacologic treatment, Allergen-specific immunotherapy (ASIT) has also been considered as a potential therapy allergic asthma. House dust mite (HDM) common airborne allergen among patients with This review focused on the relationship between HDM allergy underlying mechanism ASIT, current evidence HDM-specific It was demonstrated that risk factor associated disease development The induction immune tolerance regulatory T cells proved to play pivotal role in immunological mechanisms ASIT. Experimental studies murine models reveal not only therapeutic efficacy but preventive development. clinical trials reducing symptoms medication use. Today, application ASIT limitation when considering extent benefit systemic adverse reactions. Although sublingual extract have better safety profile comparing subcutaneous immunotherapy. To make more practicable in clinical application, further advances are needed.