Effect of immunization on susceptibility to experimental Streptococcus mutans and Streptococcus sanguis endocarditis.

摘要: It has been asserted that humoral immunity is an important potentiating factor in pathogenesis of infective endocarditis, prior immunization to certain bacteria may predispose the host endocarditis caused by those organisms. If so, possible future vaccination humans with streptococcal antigens for prevention dental caries might increase susceptibility population endocarditis. To examine this hypothesis further, we immunized rabbits killed Streptococcus sanguis or mutans. After complement-fixing antibody had developed, were tested experimental Rabbits high titers infecting organism developed less often (13%) than animals lower (69%; P 0.0002). These findings do not support pre-immunization predisposes and lend no credence concept human subjects against their On contrary, results these experiments indicate specific can confer relative