摘要: Translation of basic scientific findings into practical patient outcomes is a significant exercise even when the goal conceptually straightforward, as in development vaccine for an infectious disease. Recognition association cervical cancer with papillomavirus infection encouraged to help prevention this very common cancer, causing over 250,000 deaths each year worldwide. To introduce program, it was however necessary develop technology making viral Ag, demonstrate that systemic immunization could provide mucosal surface protection genital tract, assays potency, and understand enough about epidemiology natural history plan effective intervention strategies. This process took ∼25 years. The major hurdle, now vaccines are available, ensure their deployment countries where they most needed. human benefits collaborative research activity across globe, between academia industry, translate discoveries public health benefits.
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Harald zur Hausen, Human papillomaviruses and their possible role in squamous cell carcinomas. Current Topics in Microbiology and Immunology. ,vol. 78, pp. 1- 30 ,(1977) , 10.1007/978-3-642-66800-5_1
Shannon Stokley, Julianne Gee, C. Robinette Curtis, Maria Cano, David Yankey, Jill Roark, Lauri Markowitz, Jenny Jeyarajah, Human papillomavirus vaccination coverage among adolescents, 2007-2013, and postlicensure vaccine safety monitoring, 2006-2014--United States. Morbidity and Mortality Weekly Report. ,vol. 63, pp. 620- 624 ,(2014)
T. C. Pomfret, J. M. Gagnon Jr, A. T. Gilchrist, Quadrivalent human papillomavirus (HPV) vaccine: a review of safety, efficacy, and pharmacoeconomics Journal of Clinical Pharmacy and Therapeutics. ,vol. 36, pp. 1- 9 ,(2011) , 10.1111/J.1365-2710.2009.01150.X
M. Boshart, L. Gissmann, H. Ikenberg, A. Kleinheinz, W. Scheurlen, H. zur Hausen, A new type of papillomavirus DNA, its presence in genital cancer biopsies and in cell lines derived from cervical cancer. The EMBO Journal. ,vol. 3, pp. 1151- 1157 ,(1984) , 10.1002/J.1460-2075.1984.TB01944.X
HM Laird, WF Jarrett, BW O'Neil, JM Gaukroger, Campo, KT Smith, Studies on vaccination against papillomaviruses: a comparison of purified virus, tumour extract and transformed cells in prophylactic vaccination. Veterinary Record. ,vol. 126, pp. 449- 452 ,(1990) , 10.1136/VR.126.18.449
R Kirnbauer, J Taub, H Greenstone, R Roden, M Dürst, L Gissmann, D R Lowy, J T Schiller, Efficient self-assembly of human papillomavirus type 16 L1 and L1-L2 into virus-like particles. Journal of Virology. ,vol. 67, pp. 6929- 6936 ,(1993) , 10.1128/JVI.67.12.6929-6936.1993
Sadeep Shrestha, Sudenga, Royse, Royse, Role and uptake of human papillomavirus vaccine in adolescent health in the United States. Adolescent Health, Medicine and Therapeutics. ,vol. 2, pp. 63- 74 ,(2011) , 10.2147/AHMT.S15941
Heidi J Larson, Pauline Brocard, Geoffrey Garnett, The India HPV-vaccine suspension The Lancet. ,vol. 376, pp. 572- 573 ,(2010) , 10.1016/S0140-6736(10)60881-1
S Jablonska, S Majewski, Epidermodysplasia verruciformis: what's new? Journal of The European Academy of Dermatology and Venereology. ,vol. 17, pp. 381- 382 ,(2003) , 10.1046/J.1468-3083.2003.00702.X
J. M'Fadyean, F. Hobday, Note on the Experimental Transmission of Warts in the Dog Journal of Comparative Pathology and Therapeutics. ,vol. 11, pp. 341- 344 ,(1898) , 10.1016/S0368-1742(98)80056-8