Mass drug administration for the control and elimination of Plasmodium vivax malaria: an ecological study from Jiangsu province, China

摘要: Recent progress in malaria control has caused renewed interest mass drug administration (MDA) as a potential elimination strategy but the evidence base is limited. China extensive experience with MDA, it not well documented. An ecological study was conducted to describe use of MDA for and Plasmodium vivax Jiangsu Province explore association between incidence. Two periods were focused on: 1973 1983 when burden high administered highly endemic counties province-wide, 2000 2009, low focal approach used two counties. All available data about strategies implemented, coverage, co-interventions, incidence, adverse events collected described. Joinpoint analysis trends incidence relationship coverage explored negative binomial regression models. From 1983, pyrimethamine primaquine on large scale, up 30 million people target covered peak year (50% total population). analyses identified declines annual -56.7% (95% CI -75.5 -23.7%) from 1973–1976 -12.4% -24.7 2.0%) 1976–1983. Population average models higher population lower monthly 1973–1976, IRR 0.98 0.97 1.00), while rainfall GDP associated. 2000–2009, declined (annual change -43.7 -14.0%) during time using chloroquine targeted villages and/or individuals residing near passively detected index cases (median 0.04% Although safety systematically, there rare reports serious non-fatal events. In Province, China, large-scale implemented associated P. transmission; more recent may have contributed interruption transmission. should be considered key elimination.