Abstract B01: Immune cell infiltrates differ by obesity in tumor and adjacent normal breast tissue in African American women with triple-negative breast cancer

摘要: Introduction: Obesity is a risk factor for breast cancer, including the more aggressive triple-negative (TN) subtype, but relevance of obesity to prognosis remains unclear. Unlike other subtypes, cancer (TNBC) not hormonally responsive and characterized by lack estrogen receptor, progesterone human epidermal growth receptor-2 expression. Thus, obesity-related development TN tumors unlikely rely on peripheral aromatization androgens estrogens in fat. Chronic, low-grade inflammation elicited could increase TNBC. Here we sought assess which mechanisms mediate obesity’s effect normal tissue using gene expression approach. Because African American women are likely be obese twice as develop TNBC compared white women, understanding critical this high-risk group. Methods: We performed whole-genome profiling formalin-fixed, paraffin-embedded samples from 104 with (59 tumor, 45 adjacent normal). Body mass index was obtained medical record abstraction, BMI at least 30 kg/m2 were classified obese. Gene Ontology (GO) used identify biologic processes enriched differentially expressed genes status (p-value Results: 28 (47%) tumor 29 (64%) women. Among highly nonobese GO analysis revealed enrichment proinflammatory involving regulation immune system, activation responses, leukocyte activation, neutrophil (FDR-corrected p-value Conclusions: modifies cell environment present only also surrounding tissue. promotes setting within tumors, contrast, an anti-inflammatory adjacent. These findings may have important implications how influences prognosis, particularly among who high both. Citation Format: Asra N. Shaik, Julie L. Boerner, Michele Cote, Gregory Dyson, Rouba Ali-Fehmi, Sudeshna Bandyopadhyay, Kristen S. Purrington. Immune infiltrates differ [abstract]. In: Proceedings AACR Special Conference: Advances Breast Cancer Research; 2017 Oct 7-10; Hollywood, CA. Philadelphia (PA): AACR; Mol Res 2018;16(8_Suppl):Abstract nr B01.