Multi-element detection for supercritical fluid chromatography by inductively coupled plasma mass spectrometry

摘要: The feasibility of multi-element detection using supercritical fluid chromatography (SFC) with inductively coupled plasma mass spectrometry (ICP-MS) has been investigated for organomercury and organolead compounds. Since a quadrupole spectrometer is sequential instrument, transient signals presents difficulties; therefore, usually performed in single-ion monitoring mode. applicability utilizing time-resolved acquisition (TRA) software quantitative determinations SFC was compared results obtained modes. Detection limits were found to be approximately 5–10 pg diethylmercury (DIEM) TRA 3 detection. tetrabutyllead (TTBL) tributyllead (TRBL) acetate 0.7–3 50–100 pg, respectively, the acquisitions, 0.5 10 measurements. calibration graphs linear over three decades DIEM TTBL, two TRBL. precision technique between 1 5% relative standard deviation 5 ng injections compounds interest. accuracy SFC–ICP-MS demonstrated by analysis National Institute Standards Technology (NIST) reference material (SRM) 2715 Lead Reference Fuel, giving concentration 785 ± 9.71 ppm tetraethyllead, system, certified value 784 4.00 at 95% confidence level.