Routine Skin Cleansing with Povidone-Iodine Is Not a Common Cause of Transient Neonatal Hypothyroidism in North America: A Prospective Controlled Study

摘要: A high incidence of transient neonatal hypothyroidism has been observed in premature infants after routine skin cleansing with iodine. Because these reports have predominantly from Europe, a borderline, iodine-deficient area, we wished to determine whether this was also true North America, an iodine-sufficient area. prospective, controlled study performed babies < or = 36 weeks gestation admitted intensive care nursery. Thyroxine (T4) and thyrotropin (TSH) were measured at day 1, days 4 6, 10 12 preparation iodine noniodine-containing antiseptic solution (chlorhexidine) that served as control. If repeat required, sequence repeated. Urinary quantitated on 1 3 estimate exposure. There no difference the mean T4 concentration any time points evaluated nor between iodine-exposed (2/17) control (0/14) despite urinary excretion up 88 times value. Unexpectedly 5 but 0 developed severe hypothyroxinemia (T4 40 nmol/L), compatible sick euthyroid syndrome; one them died. We conclude that, unlike is not common sequela newborn America. This may be due prior status. Whether excessive absorption associated thyroid-independent toxic effects remains clarified.