Do changes in body mass index explain temporal trends in prevalence of wheeze and asthma

摘要: Aims The reported associations between asthma and obesity, the increasing prevalence of both conditions over time suggest that changes in body mass index (BMI) might help explaining increase wheeze children. We tested this hypothesis two population-based cohort studies conducted 8 years apart with identical methodology. Methods assessed cohorts 1-4 year old white children 1990 (N=1153) 1998 (N=2089) respectively, using questionnaires. Height weight were measured independently by health visitors. used multivariable logistic regression to calculate odds ratios (OR) for trends current (CW) doctor diagnosed (DDA), controlling confounders, without adjustment BMI z-scores (WHO child growth standards) Results Between increased slightly (-0.07 0.10, p Conclusions In our study, did not explain marked wheezing illness. Funding SNF PDFMP3-123162; 32003B-144068; Asthma UK 07/048.