Cancer in survivors of childhood soft tissue sarcoma and their relatives.

摘要: One hundred fifty-nine 3-year survivors of childhood soft tissue sarcoma and their relatives were surveyed to determine the frequency second malignant neoplasms (SMNs) in patients cancer relatives. The experience patients, offspring, siblings, parents, parental grandparents was compared that expected general population based on age-, sex- calendar year-specific rates from Connecticut Tumor Registry. A significant excess SMNs observed (observed = 8:0.38). Among 758 first-degree relatives, a (34:20.68), attributable largely bone (6:0.44) breast (9:3.39) cancers occurring before age 35 years (12:4.14). Overall, significantly lower than incidence confirmed 1,693 second-degree (142:178). To identify patient characteristics associated with higher familial risk, kindreds partitioned by at diagnosis tumor type, site SMN other factors. highly (26:12.78). types close also as patients. findings confirm an association among breast, bone, joint, or suggest risk is predisposition cancer.