Impact of zidovudine treatment and the pneumocystis carinii prophylaxis in natural history of patients with HIV infection

摘要: INTRODUCTION Early use of prophylactic regimens against Pneumocystis carinii and zidovudine therapy, may have modified the natural history patients with HIV-1 infection. We describe incidence opportunistic infections analize mortality rate in those to check occurrence any change above mentioned history. PATIENTS Clinical charts infection attending our hospital are reviewed, from november 1987 june 1994. RESULTS found 200 AIDS, documenting 64 (32%) deaths 69 (34.5%) lost follow-up. Seven infected (3.5%) received primary prophylaxis 17 (8.5%) therapy before developing AIDS. Patients AIDS receiving had a higher survival (median 50 months) than not such months; p < 0.001). Ninety one tuberculosis also antirretroviral (p 0.01). Eighty six pneumonia Likewise, on treatment lower reduction CD4 lymphocyte count. CONCLUSIONS The spectrum AIDS-defining illnesses is similar whole country. difference infections, but we observed trend PCP. introduction seems positive influence patients. This advantage highlighted more immunodeficients at first.