In Vitro Fertilization Improves Childhood Growth and Metabolism

摘要: Background: There is limited information regarding the long-term outcome of children born after in vitro fertilization (IVF), although an increase rare imprinted gene disorders such as Beckwith-Wiedemann syndrome has been reported. Methods: We recruited healthy, prepubertal at term singleton pregnancy. The study group were conceived using IVF with fresh embryo transfer, whereas controls naturally conceived. Anthropometric measurements, bone age, dual-energy x-ray absorptiometry, fasting serum glucose, insulin, lipid profile, IGF-I and -II, IGF-binding proteins 1, 2, 3 performed. Results: 69 aged 5.9 ± 0.2 yr 71 control 6.9 yr. taller than when corrected for parents’ heights (height sd score 1.05 0.1 vs. 0.51 0.11, P = 0.001) higher levels IGF-II (850 24 773 μg/liter, 0.03), to protein ratio (P 0.04), a trend towar...