Hepatocyte growth factor overexpression promotes osteoclastogenesis and exacerbates bone loss in CIA mice.
作者： Chaoming Huang , Yufan Zheng , Jinyu Bai , Ce Shi , Xin Shi
DOI: 10.1016/J.JOT.2020.10.011
关键词:
摘要: Abstract Background Hepatocyte growth factor (HGF) is a multifunctional that promotes various biological processes. However, the effect of HGF on bone metabolism in rheumatoid arthritis (RA) remains unknown. Here, we investigated role regulating osteoclastogenesis and resorption RA. Methods The expression RA patients collagen-induced (CIA) mice was examined. analysed by assays. inhibition evaluated CIA model. mechanism explored series vitro studies. Results overexpressed stimulated vitro. SU11274, selective small molecule blocker c-Met, impeded resorption. regulated JNK AKT-GSK-3β-NFATc1 signallings. SU11274 protected from pathological loss. Conclusions These data strongly suggest highly expressed joint tissues contributes to loss Inhibition HGF/c-Met could effectively alleviate inflammatory symptoms mice. may be used as new target for treatment
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