Cooperation and interplay between base and nucleotide excision repair pathways: From DNA lesions to proteins

摘要: Base and nucleotide excision repair (BER NER) pathways are normally associated with removal of specific types DNA damage: small base modifications (such as those induced by oxidation) bulky lesions ultraviolet or chemical carcinogens), respectively. However, growing evidence indicates that this scenario is much more complex these exchange proteins cooperate each other in the lesions. In review, we highlight studies discussing involvement NER damage oxidative stress, BER participating adducts on DNA. Adding to complexity, UVA light experiments revealed stress also causes protein oxidation, directly affecting involved both BER. This reduces cell's ability deleterious implications cells, such mutagenesis cell death, organisms, cancer aging. Finally, an interactome presented, showing strong connection between pathways, indicating further investigation may reveal new functions shared them, their cooperation maintaining genome stability.