The miRacle in Pancreatic Cancer by miRNAs: Tiny Angels or Devils in Disease Progression

摘要: Pancreatic ductal adenocarcinoma (PDAC) is an aggressive malignancy with increasing incidence and high mortality. Surgical resection the only potentially curative treatment of patients PDAC. Because late presentation disease, about 20 percent are candidates for this treatment. The average survival resected between 12 months, a probability relapse. Standard chemo radiation therapies do not offer significant improvement these patients. Furthermore, novel options aimed at targeting oncogenes or growth factors in pancreatic cancer have proved unsuccessful. Thereby, identifying new biomarkers that can detect early stages disease critical importance. Among biomarkers, microRNAs (miRNAs) supplied profitable recourse become attractive focus research MiRNAs regulate many genes involved development PDAC through mRNA degradation translation inhibition. possibility intervention molecular mechanisms miRNAs regulation could begin generation therapies. This review summarizes reports describing involvement cellular processes involving carcinogenesis their utility diagnosis, therapeutic potential cancer.