miR-221/222 Target the DNA Methyltransferase MGMT in Glioma Cells

作者: Cristina Quintavalle , Davide Mangani , Giuseppina Roscigno , Giulia Romano , Angel Diaz-Lagares

DOI: 10.1371/JOURNAL.PONE.0074466

关键词:

摘要: … unknown microRNA-mediated mechanism of MGMT expression … -221 expression and MGMT downregulation, we performed a … with outcome in glioblastomas given temozolomide and …

参考文章(38)
David N. Louis, WHO classification of tumours of the central nervous system International Agency for Research on Cancer. ,(2007)
Kunihiko Sakumi, Teruhisa Tsuzuki, Takatoshi Ishikawa, Seiichiro Shimizu, Akiko Shiraishi, Mutsuo Sekiguchi, Mutsuo Sekiguchi, Methylnitrosourea-induced Tumorigenesis in MGMT Gene Knockout Mice Cancer Research. ,vol. 57, pp. 2415- 2418 ,(1997)
Yasumitsu Takagi, Masayuki Takahashi, Masayuki Sanada, Riyoko Ito, Masaru Yamaizumi, Mutsuo Sekiguchi, Roles of MGMT and MLH1 proteins in alkylation-induced apoptosis and mutagenesis DNA Repair. ,vol. 2, pp. 1135- 1146 ,(2003) , 10.1016/S1568-7864(03)00134-4
Maciej M Mrugala, Marc C Chamberlain, Mechanisms of disease: temozolomide and glioblastoma--look to the future. Nature Reviews Clinical Oncology. ,vol. 5, pp. 476- 486 ,(2008) , 10.1038/NCPONC1155
M. Negrini, M. Ferracin, S. Sabbioni, C. M. Croce, MicroRNAs in human cancer: from research to therapy Journal of Cell Science. ,vol. 120, pp. 1833- 1840 ,(2007) , 10.1242/JCS.03450
Roger Stupp, Monika E. Hegi, Brain cancer in 2012: Molecular characterization leads the way. Nature Reviews Clinical Oncology. ,vol. 10, pp. 69- 70 ,(2013) , 10.1038/NRCLINONC.2012.240
M GAROFALO, G CONDORELLI, C CROCE, MicroRNAs in diseases and drug response. Current Opinion in Pharmacology. ,vol. 8, pp. 661- 667 ,(2008) , 10.1016/J.COPH.2008.06.005
P. Pineau, S. Volinia, K. McJunkin, A. Marchio, C. Battiston, B. Terris, V. Mazzaferro, S. W. Lowe, C. M. Croce, A. Dejean, miR-221 overexpression contributes to liver tumorigenesis Proceedings of the National Academy of Sciences of the United States of America. ,vol. 107, pp. 264- 269 ,(2010) , 10.1073/PNAS.0907904107
Stanton L. Gerson, Clinical Relevance of MGMT in the Treatment of Cancer Journal of Clinical Oncology. ,vol. 20, pp. 2388- 2399 ,(2002) , 10.1200/JCO.2002.06.110
J Dunn, A Baborie, F Alam, K Joyce, M Moxham, R Sibson, D Crooks, D Husband, A Shenoy, A Brodbelt, H Wong, T Liloglou, B Haylock, C Walker, Extent of MGMT promoter methylation correlates with outcome in glioblastomas given temozolomide and radiotherapy. British Journal of Cancer. ,vol. 101, pp. 124- 131 ,(2009) , 10.1038/SJ.BJC.6605127