A Review on Adducin from Functional to Pathological Mechanisms: Future Direction in Cancer.

摘要: Adducin (ADD) is a family of membrane skeleton proteins including ADD1, ADD2, and ADD3 that are encoded by distinct genes on different chromosomes. primarily responsible for the assembly spectrin-actin network provides physical support to plasma mediates signal transduction in various cellular physiological processes upon regulation protein kinase C-dependent calcium/calmodulin-dependent pathways. Abnormal phosphorylation, genetic variations, alternative splicing adducin may contribute alterations functions involved pathogenic processes. These associated with wide range diseases cancer. This paper begins discussion how partakes structural formation skeleton, its regulation, related functional characteristics, followed review pathogenesis hypertension, biliary atresia, cancer respect increased disease susceptibility mediated polymorphism and/or dysregulation. Given diversity compartments, we aim provide knowledge base whereby pathophysiological roles can be better understood. More importantly, novel insights significance turning model clinical application.