Impaired proinsulin secretion before and during oral glucose stimulation in HIV-infected patients who display fat redistribution.
作者： Steen B. Haugaard , Ove Andersen , Ian Halsall , Johan Iversen , Charles Nicholas Hales
DOI: 10.1016/J.METABOL.2007.02.007
关键词:
摘要: The beta-cell function of HIV-infected patients on highly active antiretroviral therapy who display lipodystrophy may be impaired. An early defect in characterized by an increase secretion 32-33 split proinsulin (SP) and intact (IP). To address this issue, the patterns SP IP 16 men with (LIPO) 15 without (NONLIPO) were studied during oral glucose tolerance test (OGTT). All received therapy. Insulin rates determined deconvolution plasma C-peptide concentrations. More LIPO than NONLIPO displayed diabetes mellitus impaired normal (LIPO 2/8/6 vs 1/2/12, P = .05). had increased fasting levels IP, ratio SP/IP, area under curve phase (0, 10, 20 minutes) late (45, 75, 105 OGTT compared (Ps < exhibited significantly SP/IP ratio, SP/insulin total to OGTT. incremental first 10 minutes (P .05), although insulin period did not differ between patients. These data suggest that major perturbations state OGTT, which is compatible notion a dysfunction such
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