Imaging Experimental Brain Metastases

摘要: Studies of the metastatic process and potential cancer therapies have been advanced by use imaging technology that enables noninvasive assessment tumor development over time. Several modalities used to examine brain metastases in preclinical models. Magnetic resonance (MRI) is clinical gold standard for anatomical evaluation metastases. New advances MRI MR spectroscopy (MRS) now enabled physiological characteristics tumors be investigated including permeability, vascularity, cellularity metabolism as well cerebral blood flow volume. can also detect single iron-labeled cells after their initial arrest mouse subsequent development. Nuclear techniques positron emission tomography (PET) photon computed (SPECT) are popular tools classifying monitoring treatment. Brain assessed bio­chemical alterations such glucose use, DNA synthesis, amino acid transport oxygenation state. Optical based on fluorescent or bioluminescent reporters found advantageous burden experimental animals. Fluorescent entities ­further intravital microscopy track monitor relationship between vasculature, cell arrest, early extravasation, perpetuation a perivascular position either angiogenesis vessel co-option. Finally, studies often improved using multiple concurrently, thereby exploiting best features separate acquire multilayered information provide further insights into evolution