Catalytic Asymmetric Construction of β-Amino Acid Precursors and Their Use in an Iterative Method Towards β-Peptide Synthesis
作者： Joanne Bertonazzi
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摘要: Towards the goal of novel β-peptide synthesis, a method to access variety enantioenriched β-amino acid precursors was developed. These were then utilized in synthesis numerous β-peptides solution and on solid support. The allowing this unique technology are thiazinone β-lactam heterocycles which accessed via asymmetric cycloadditions N-acyl imines ketenes utilizing cinchona alkaloid catalysts. methodology developed herein provides previously unavailable acids β-peptides.
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