Inflammatory Response to Polymeric Materials

摘要: The inflammatory response is historically defined as “A tissue reaction that results in rubor, calor, dolor and functio laesa.” This nonspecific characterized by the activation of complement system, chemotactic attraction phagocytes, an increased vascular permeability. It consists a series primarily local events occurring normal expected from organism healthy individual for its self-protection against any foreign attack, allowing isolation body elimination injured cells, preparing repair. Thus, plays pivotal role biocompatibility material considered body. In addition to initial injury induced introduction into living persistent presence contact with induces which can remain local, benign, short, or become systemic, persistent, health-threatening. A optimal should not add response, nor prevent time-dependent process. starts acute phase, followed chronic end Different types ions, proteins, mediators, leukocytes are involved during different phases. rate, intensity duration at molecular level surroundings