Increased left atrial volume index is an independent predictor of raised serum natriuretic peptide in patients with suspected heart failure but normal left ventricular ejection fraction: Implication for diagnosis of diastolic heart failure

摘要: Background: Left atrial volume index (LAVI) is increasingly recognised as a relatively load-independent marker of left ventricular (LV) filling pressures. We assessed the capacity LAVI to predict LV diastolic dysfunction in comparison with N-terminal pro B-type natriuretic peptide (NTproBNP) patients suspected heart failure and normal ejection fraction (EF). Methods: 137 (HF), referred from community for echocardiography, prospectively underwent Doppler NTproBNP estimation. Raised reduced systolic function were defined >26 ml/m2 EF <50% respectively. Results: Of 137 patients, 21 excluded (2 significant mitral valve disease 19 fibrillation). Of remaining 116 subjects, 92 showed function. The univariate predictors serum log age (p 26ml/m2 was 0.81 without LVEF ≥50% 0.82 (p<=0.0001). Conclusion: This data confirms that on resting specifically HF powerful independent predictor predicted by NTproBNP. In population high suspicion failure, may significantly contribute diagnostic precision.