Anti-Pneumocystis carinii pneumonia activity of dicationic carbazoles
作者： DA Patrick , DW Boykin , WD Wilson , FA Tanious , J Spychala
DOI: 10.1016/S0223-5234(99)80064-6
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摘要: Summary A series of 2,7- and 3,6-bis cationic carbazoles was synthesized evaluated for activity against a rat model Pneumocystis carinii pneumonia (PCP). The compounds were also tested inhibition topoisomerase II binding to DNA. Several the proved be more potent less toxic than standard anti-PCP drug (pentamidine). While no quantitative correlation seen between activity, DNA binding, minimal level found necessary antimicrobial activity.
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