Menthol and nicotine oppositely modulate body temperature in the rat
作者： David N. Ruskin , Rene Anand , Gerald J. LaHoste
DOI: 10.1016/J.EJPHAR.2007.01.006
关键词:
摘要: Abstract Menthol is a prominent additive in many tobacco products. To investigate possible interactions with nicotine, (−)-menthol (200 or 400 mg/kg) and (−)-nicotine (0.5 mg/kg) were injected subcutaneously rats, body temperature, which modulated by brain nicotinic acetylcholine receptors, was measured. Nicotine caused robust (− 1.6 °C) hypothermia, the magnitude time course of not altered menthol pretreatment. alone produced mild (0.4–0.8 °C) hyperthermia, secondary to locomotor activation. influence temperature independently oppositely; does appear function central receptors that control temperature.
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