Astrocytes in infectious and immune-mediated diseases of the central nervous system.

摘要: The central nervous system (CNS) can be invaded and damaged by a variety of microbes. host response to such injury involves CNS cells, in many cases hematogenous cells also. Recent experiments indicate that astrocytes, macroglial resident the CNS, play key roles this process. astroglial production trophic factors elimination neurotoxins are likely fulfill important protective reparative functions during infection. In addition, astrocytes could, concert with microglial regulate recruitment activity infiltrating through their expression cytokines, proteases, protease inhibitors, adhesion molecules, extracellular matrix components. Although previous suggested might initiate inflammatory demyelinating disease presenting antigens autoreactive immune current evidence points against detrimental activity. view generally beneficial role impairments...