Limonene GP1/PG organogel as a vehicle in transdermal delivery of haloperidol.

摘要: Penetration enhancers are a classical means for improving transdermal drug delivery (TDD). Enhancers permeate into the skin and reversibly decrease barrier resistance. Basically, our aim is to formulate gel containing an appropriate enhancer controlled release. Terpenes, namely limonene, linalool cineole, in propylene glycol (PG) were first investigated vitro their capacity enhance percutaneous release of anti-psychotic drug, haloperidol (HP). Relative oxygenated hydrocarbon limonene was more effective as enhancer; it increased human permeability decreased lag time. Limonene thus incorporated organogel comprised gelator GP1 PG. This skin-friendly patch could act long-acting formulation that delivers HP at sustained rate. The microscopic framework branched network interlocking fibres. Varying content modulates fibre density stiffness, presents different degrees resistance diffusion on vehicle side. Rheological permeation studies demonstrated increase concentration moduli flux simultaneously. rheology matrix influenced rate manner described by several experimentally-derived correlations.