Upregulation and Nuclear Recruitment of HDAC1 in Hormone Refractory Prostate Cancer
作者： Kalipso Halkidou , Luke Gaughan , Susan Cook , Hing Y. Leung , David E. Neal
DOI: 10.1002/PROS.20022
关键词:
摘要: BACKGROUND Histone deacetylase 1 (HDAC1) is a co-repressor involved in differentiation and proliferation control. It upregulated malignant compared to benign tissue, targets number of transcription factors including p53. METHODS By immunohistochemistry, HDAC1 protein expression was investigated human prostate specimens the CWR22 mouse xenograft model. Flow cytometry deconvolution immunofluorescence were also performed. RESULTS HDAC1 pre-malignant lesions, with highest increase hormone refractory (HR) cancer. Using model we showed androgen dependent regulation HDAC1. overexpression led significant shift towards undifferentiated cytokeratin (CK) profile PC3M derivative clone constitutively expressing HDAC1. CONCLUSION This study underlines importance cell development cancer (CaP) proposes mechanism for nuclear recruitment. may constitute crucial therapeutic target particularly most lethal phase independence. © 2004 Wiley-Liss, Inc.
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