Redox regulation of protein kinases
作者： Thu H. Truong , Kate S. Carroll
DOI: 10.3109/10409238.2013.790873
关键词:
摘要: AbstractProtein kinases represent one of the largest families genes found in eukaryotes. Kinases mediate distinct cellular processes ranging from proliferation, differentiation, survival, and apoptosis. Ligand-mediated activation receptor can lead to production endogenous hydrogen peroxide (H2O2) by membrane-bound NADPH oxidases. In turn, H2O2 be utilized as a secondary messenger signal transduction pathways. This review presents an overview molecular mechanisms involved redox regulation protein its effects on signaling cascades. first half, we will focus primarily tyrosine (RTKs), whereas latter concentrate downstream non-receptor relaying stimulant response. Select examples literature are used highlight functional role regarding kinase activity, well components during signaling. addition, studies demonstra...
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