Microbiota that affect risk for shigellosis in children in low-income countries

摘要: Pathogens in the gastrointestinal tract exist within a vast population of microbes. We examined associations between pathogens and composition gut microbiota as they relate to Shigella spp./enteroinvasive Escherichia coli infection. analyzed 3,035 stool specimens (1,735 nondiarrheal 1,300 moderate-to-severe diarrheal) from Global Enteric Multicenter Study for 9 enteropathogens. Diarrheal had higher number enteropathogens (diarrheal mean 1.4, 0.95; p<0.0001). Rotavirus showed negative association with spp. cases diarrhea (odds ratio 0.31, 95% CI 0.17–0.55) large combined effect on 29, 3.8–220). In 4 Lactobacillus taxa identified by 16S rRNA gene sequencing, associa tion pathogen disease was decreased, which is consistent possibility that are protective against spp.–induced diarrhea. Bacterial diversity associated status, not high levels ipaH gene. D