A selective drug delivery system based on phospholipid-type nanobubbles for lung cancer therapy.
作者： Ming-Hsien Chan , Yung-Chieh Chan , Ru-Shi Liu , Michael Hsiao
关键词:
摘要: Aim: To develop a micelle-type nanobubble decorated with fluorescein-5-isothiocyanate-conjugated transferrin, encapsulation of paclitaxel (PTX@FT-NB) for lung cancer treatment. Materials & methods: PTX@FT-NBs were characterized to determine their physicochemical properties, structural stability and cytotoxicity. Lung cell mouse xenograft tumor models used evaluate the therapeutic effectiveness PTX@FT-NB. Results: The not only showed selective targeting cells but also inhibited growth significantly via release. Furthermore, paclitaxel-induced microtubule stabilization demonstrated release drug from PTX@FT-NB in targeted both vitro vivo. Conclusion: has potential as an anticancer nanocarrier against because its specific better delivery capacity.
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