Microalbuminuria: Marker or Maker of Cardiovascular Disease

摘要: Advancing age is associated with albuminuria and vascular changes. This review will explore the putative links between two. Vascular ageing involves endothelial dysfunction as well increased arterial diameter, wall thickness stiffness, ultimately leading to sclerosis. process accelerated by a defective repair process. Endothelial likely be involved in initiation development of microalbuminuria. It often followed progression atherosclerosis. Initially, microalbuminuria reversible but becomes fixed structural changes including glomerulosclerosis. The prevalence increases has been shown marker widespread microvasculopathy at various levels cerebral, cardiac renal microcirculations. linked endpoint clinical events, increasing risk cognitive impairment strokes, cardiovascular disease outcomes, end-stage failure. Evidence microvascular damage such may suggest that predate overt macrovascular disease. Microalbuminuria reduced glomerular filtration rate (GFR) markers different pathologic processes. GFR simply represent, respectively, spectrum manifestations from systemic (microvascular disease) atherosclerosis (macrovascular disease).